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Article

Disease-associated polymorphisms in 9p21 are not associated with extreme longevity.

Geriatrics & gerontology international - 1 Jun 2015

Congrains Ada, Kamide Kei, Hirose Nobuyoshi, Arai Yasumichi, Oguro Ryousuke, Nakama Chikako, Imaizumi Yuki, Kawai Tatsuo, Kusunoki Hiroshi, Yamamoto Hiroko, Onishi-Takeya Miyuki, Takeya Yasushi, Yamamoto Koichi, Sugimoto Ken, Akasaka Hiroshi, Saitoh Shigeyuki, Miura Tetsuji, Awata Nobuhisa, Kato Norihiro, Katsuya Tomohiro, Ikebe Kazunori, Gondo Yasuyuki, Rakugi Hiromi

Abstract excerpt

AIM: The 9p21 region has been pointed out by the genome-wide association studies as a hot spot for disease-associated variants. Most of the diseases linked with the locus are aging-related conditions, such us cardiovascular disease, diabetes and cancer. Centenarians are known to present a reduced risk and delayed onset for these conditions. Here, we aimed to assess if the 9p21 variants contribute to this...

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PMID: 25257646
DOI: 10.1111/ggi.12346

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