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Locus 9p21.3 CAD Risk Across Diverse Populations: LD and Allelic Heterogeneity Explain Variation Across Ancestries and Reduced Replication in Africans

2026-01-03

Abstract excerpt

<h4>Background:</h4> The 9p21.3 locus was the first genome-wide significant signal for coronary artery disease (CAD) and replicates across multiple non-African populations, yet is absent in African ancestry cohorts. We hypothesized that ancestry-specific linkage disequilibrium (LD) and haplotype structure, rather than allele frequency or power alone, explain this discrepancy. <h4>Methods:</h4> We analyzed multi-...

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Literature Corpus work: 77ced53b-b2ef-5798-861f-8a1214474a02
DOI: 10.64898/2026.01.02.25343215

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