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Article

Effect of longevity genetic variants on the molecular aging rate.

GeroScience - 1 Jun 2021

Gurinovich Anastasia, Song Zeyuan, Zhang William, Federico Anthony, Monti Stefano, Andersen Stacy L, Jennings Lori L, Glass David J, Barzilai Nir, Millman Sofiya, Perls Thomas T, Sebastiani Paola

Abstract excerpt

We conducted a genome-wide association study of 1320 centenarians from the New England Centenarian Study (median age = 104 years) and 2899 unrelated controls using >9 M genetic variants imputed to the HRC panel of ~65,000 haplotypes. The genetic variants with the most significant associations were correlated to 4131 proteins that were profiled in the serum of a subset of 224 study participants using a SOMAscan...

Topics

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Aged, 80 and over
Aging
APOB gene
CDKN2A gene
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33948810
DOI: 10.1007/s11357-021-00376-4
PMCID: PMC8190315

Genes

APOB
APOE
CDKN2A
CDKN2B
GDF15
HRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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