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Article

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

American journal of human genetics - 6 Aug 2026

Alkhairo Hasan, Koyama Satoshi, Iyer Kruthika, Hilliard Austin T, Kho Pik Fang, Clarke Shoa, Abdulwahab Firdous M, Assimes Themistocles L, Lynch Julie A, Ramsay Michèle, Chang Kyong-Mi, Tsao Philip S, Alkuraya Fowzan S, Ito Kaoru, Risch Neil, Tcheandjieu Catherine

Abstract excerpt

Locus 9p21.3 was the first genome-wide significant locus for coronary artery disease (CAD) and replicates across multiple non-African populations, yet it is absent in African-ancestry cohorts. We analyzed multi-ancestry data from European, East Asian, South Asian, Middle Eastern, African, and admixed American groups. Ancestry was inferred using both global and local-ancestry inference (LAI) approaches. Within...

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Identifiers

PMID: 42385718
DOI: 10.1016/j.ajhg.2026.06.007
PMCID: PMC13504348

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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