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Article

Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians.

Aging cell - 1 Oct 2023

Zhu Yizhou, Ryu Seungjin, Tare Archana, Barzilai Nir, Atzmon Gil, Suh Yousin

Abstract excerpt

Genome-wide association studies (GWAS) have pinpointed the chromosomal locus 9p21.3 as a genetic hotspot for various age-related disorders. Common genetic variants in this locus are linked to multiple traits, including coronary artery diseases, cancers, and diabetes. Centenarians are known for their reduced risk and delayed onset of these conditions. To investigate whether this evasion of disease risks involves...

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Identifiers

PMID: 37605876
DOI: 10.1111/acel.13962
PMCID: PMC10577543

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