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Article

Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.

Mechanisms of ageing and development - 1 Oct 2013

Han Jeehae, Ryu Seungjin, Moskowitz David M, Rothenberg Devorah, Leahy Daniel J, Atzmon Gil, Barzilai Nir, Suh Yousin

Abstract excerpt

Despite evidence of a substantial genetic component, the genetic factors that underlie longevity in humans remain to be identified. Previous genome-wide linkage and association studies have not found strong evidence for the contribution of common variants besides the APOE gene, suggesting the role of rare variants in human longevity. To discover rare variants that might contribute to longevity, we selected 988...

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Aged, 80 and over
APOE gene
PMS2 gene
Genotype
Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

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Open in PubMed Open full text

Identifiers

PMID: 23376243
DOI: 10.1016/j.mad.2013.01.005
PMCID: PMC3787996

Genes

APOE
GABRR3
PMS2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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