Article

A single-cell atlas of the human brain in Alzheimer’s disease and its implications for personalized drug repositioning

2022-06-16

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disease with complex pathophysiology, and AD-dysregulated pathways are inconsistent across different brain regions and patients. Although single-cell RNA sequencing (scRNA-seq) has been performed in different regions of postmortem AD brains, the common and distinct molecular features among different regions remains largely unclear. This hinders the discovery of repur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0b71519-1d57-5674-99d6-0d856537b7cb
DOI: 10.1101/2022.06.14.496100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell atlas of the human brain in Alzheimer’s disease and its implications for personalized drug repositioningDOI 10.1101/2022.06.14.496100Read

The Alzheimer's Cell Atlas (TACA): A single‐cell molecular map for translational therapeutics accelerator in Alzheimer's diseaseSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

scREAD: A single-cell RNA-Seq database for Alzheimer’s DiseaseSemantic proximity Read

A Single-cell and Spatial RNA-seq Database for Alzheimer’s Disease (ssREAD)Semantic proximity Read

Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomesSemantic proximity Read

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseasesSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer’s diseaseSemantic proximity Read

Human brain single nucleus cell type enrichments in neurodegenerative diseasesSemantic proximity Read

Single-cell transcriptomic analysis of Alzheimer’s diseaseSemantic proximity Read

Single-cell multiomics reveals disrupted glial gene regulatory programs in Alzheimer’s disease via interpretable machine learningSemantic proximity Read