Article

Genome-wide Nucleosome Positioning and Associated Features uncovered with Interpretable Deep Residual Networks

2024-02-12

Abstract excerpt

Nucleosomes represent elementary building units of eukaryotic chromosomes and consist of DNA wrapped around a histone octamer flanked by linker DNA segments. Nucleosomes are central in epigenetic pathways and their genomic positioning is associated with regulation of gene expression, DNA replication, DNA methylation and DNA repair, among other functions. Building on prior discoveries, that DNA sequences noticeably...

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Literature Corpus work: 5b279a79-69b9-5959-9fde-7db59d7f5910
DOI: 10.1101/2024.02.09.579668

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