Article

Familial Alzheimer’s disease mutation undermines axonal transport by enhancing dynactin recruitment to the APP motor assemblies

2022-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Experiments in flies, mice and humans suggest a significant role of impaired axonal transport in the pathogenesis of Alzheimer’s disease (AD), however, the underlying mechanisms remain unknown 1,2 . We report that the Swedish familial AD (FAD) mutation perturbs fast anterograde axonal transport of the amyloid precursor protein (APP) by altering directionality of its movement. APP thus spends mo...

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Literature Corpus work: c1ed1f45-1148-529a-86ed-246b05cdb75b
DOI: 10.1101/2022.11.17.516829

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