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Glucocerebrosidase reduces the spread of protein aggregation in a <i>Drosophila melanogaster</i> model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

2020-05-15

Abstract excerpt

Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson’s disease (PD). The spread of protein aggregates in the brain is associated with clinical disease progression, but how this occurs remains unclear. Mutations in the gene glucosidase, beta acid 1 ( GBA ), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the most penetrant common genetic risk factor for PD and de...

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Literature Corpus work
e39c00fc-a000-521f-a0a4-5a3363c6c87b
DOI
10.1101/2020.05.15.097766
Open publication

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Glucocerebrosidase reduces the spread of protein aggregation in a <i>Drosophila melanogaster</i> model of neurodegeneration by regulating proteins trafficked by extracellular vesiclesDOI 10.1101/2020.05.15.097766
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