Article

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

2018-08-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A recent human exome-chip study on plasma lipids identified a missense mutation in the A1CF (APOBEC1 complementation factor) gene that is associated with elevated triglyceride (TG) levels, but how A1CF, an RNA binding protein, influences plasma TG is unknown. <h4>Methods</h4> We generated A1cf knockout ( A1cf −/− ) mice and knock-in mice homozygous for the TG-associated...

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Literature Corpus work: 586a54a6-b380-51f7-b89a-524c29b4dd0a
DOI: 10.1101/397554

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