Article

The COPI coatomer influences LDL receptor activity, hepatic lipid storage, and apoB secretion

2026-06-03

Abstract excerpt

<h4>Background</h4> Decreased hepatic removal of low density lipoproteins (LDL) and increased apolipoprotein B (apoB) production cause hypercholesterolemia, a major causal risk factor of atherosclerotic cardiovascular disease (ASCVD). By a genome-wide siRNA screen, we previously identified subunits of the Coat protein I (COPI) complex to limit LDL uptake into Huh-7 hepatocarcinoma cells. <h4>Methods</h4> These f...

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Literature Corpus work: 2beca638-a22e-527b-b8e4-53fb892b1347
DOI: 10.64898/2026.05.30.728950

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