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Article

Functional genomic analysis reveals HAVCR1 as the key regulator of 5q33.3 locus linked to hyperlipidemia.

HGG advances - 9 Jul 2026

Chen Wei-Ting, Hsiung Chia-Ni, Jou Yuh-Shan, Wang Hui-Chun, Shen Chen-Yang, Chou Wen-Cheng

Abstract excerpt

Hyperlipidemia is a major risk factor for atherosclerosis and other serious cardiovascular diseases, yet it often presents without obvious symptoms in the absence of comorbidities, complicating early detection and management. Given the high heritability of lipid traits, genome-wide association studies (GWASs) have identified numerous loci associated with serum lipids; however, pinpointing the causal variants...

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Identifiers

PMID: 42186223
DOI: 10.1016/j.xhgg.2026.100630
PMCID: PMC13262158

Genes

HAVCR1
GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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