Systematic mapping of genetic interactions for <i>de novo</i> fatty acid synthesis

Abstract excerpt

<h4>ABSTRACT</h4> The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases including cancer. While several translational efforts have focused on direct perturbation of de novo fatty acid synthesis, only modest responses have been associated with mono-therapies. Since cancer cells are intrinsically buffered to combat metabolic stress, cells may adapt to loss of de novo fatty...

Topics

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• Breast Neoplasms
• Cancer, Lipids, and Metabolism
• Cell Movement
• Cell Proliferation
• CRISPR-Cas Systems
• MCF-7 Cells
• Mutation
• Transcriptome

Identifiers and source

Literature Corpus work

532905f4-7075-53b6-ac4b-e6233ce09072

DOI

10.1101/834721