Article

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion <i>in vitro</i> and in mouse liver

2023-12-07

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Objectives</h4> Triglyceride (TG) association with apolipoprotein B100 (apoB100) serves to form very low density lipoproteins (VLDL) in the liver. The repertoire of factors that facilitate this association is incompletely defined. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discovered as a factor participating in cytoplasmic lipid droplets (LDs) in tissu...

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Literature Corpus work: 330ae9e5-0da0-502e-b8e6-8bcb01a0504b
DOI: 10.1101/2023.12.05.570183

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