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ADAR RNA editing for cardiovascular disease: Targeting <i>B4GALT1</i> to modulate lipid metabolism through reduced galactosyltransferase activity

2025-10-31

Abstract excerpt

Cardiovascular disease remains a leading cause of mortality despite current therapies targeting low-density lipoprotein cholesterol (LDL-C). Beta-1,4-galactosyltransferase 1 (B4GALT1), a central glycosyltransferase enzyme that regulates lipoprotein metabolism and hemostasis, is a promising therapeutic target. To evaluate its therapeutic potential as a protective variant, B4galt1 p.Asn352Ser was introduced into th...

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Identifiers and source

Literature Corpus work
09b4e107-2268-5d19-8a3e-31d517084943
DOI
10.1101/2025.10.30.685343
Open publication

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ADAR RNA editing for cardiovascular disease: Targeting <i>B4GALT1</i> to modulate lipid metabolism through reduced galactosyltransferase activityDOI 10.1101/2025.10.30.685343
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