Article

EDEM3 modulates plasma triglyceride level through its regulation of LRP1 expression

2019-08-31

Abstract excerpt

<h4>Summary</h4> Human genetics studies have uncovered genetic variants that can be used to guide biological research and prioritize molecular targets for therapeutic intervention for complex diseases and metabolic conditions. We have identified a missense variant (P746S) in EDEM3 associated with lower blood triglyceride (TG) levels in >300,000 individuals. Functional analyses in cell and mouse models show that...

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Literature Corpus work: e767b99e-8491-55ea-8f47-5ee51f2e151c
DOI: 10.1101/742353

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