Article

Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic Steatosis

2026-01-26

Abstract excerpt

<h4>Summary</h4> Obesity is a major driver of hepatic steatosis, yet the molecular link between excess adiposity and hepatocellular lipid accumulation remains incompletely defined. Here, we identify circulating fatty acid–binding protein 4 (FABP4) as a key mediator of adipocyte–hepatocyte lipid crosstalk in obesity. Analyses of human liver specimens and mouse models reveal aberrant accumulation of FABP4 protein—b...

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Literature Corpus work: 09473f8c-e016-54f0-a9c3-ca57f44f3281
DOI: 10.64898/2026.01.24.701451

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