Article

Epigenetic heterogeneity shapes the transcriptional landscape of regional microglia

2024-08-09

Abstract excerpt

Microglia, the innate immune cells in the central nervous system, exhibit distinct transcriptional profiles across brain regions that are important for facilitating their specialized function. There has been recent interest in identifying the epigenetic modifications associated with these distinct transcriptional profiles, as these may improve our understanding of the underlying mechanisms governing the functional...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 585414a6-2b56-56b4-a7a4-bc432ce2739e
DOI: 10.1101/2024.08.08.607229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic heterogeneity shapes the transcriptional landscape of regional microgliaDOI 10.1101/2024.08.08.607229Read

Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with geneticsSemantic proximity Read

CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disordersSemantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

Microglial plasticity governed by state-specific enhancer landscapesSemantic proximity Read

A map of transcriptional heterogeneity and regulatory variation in human microgliaSemantic proximity Read

Differential usage of DNA modifications in neurons, astrocytes, and microgliaSemantic proximity Read

Histone deacetylase 3 regulates microglial function through histone deacetylationSemantic proximity Read

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programsSemantic proximity Read

Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brainSemantic proximity Read

Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signaturesSemantic proximity Read

Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detectionSemantic proximity Read

Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer’s DiseaseSemantic proximity Read