Article

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

2024-04-16

Abstract excerpt

The adult human central nervous system (CNS) is remarkably complex, with neural cells displaying extensive transcriptional heterogeneity. However, how different layers of epigenetic regulation underpin this heterogeneity is poorly understood. Here, we profile the adult human CNS from distinct regions, for chromatin accessibility at the single-nuclei level. In addition, we simultaneously co-profiled the histone mod...

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Literature Corpus work: 93bb5736-6d03-59c8-b4a5-f0792cba0203
DOI: 10.1101/2024.04.15.589512

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Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programsDOI 10.1101/2024.04.15.589512Read

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