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Article

Functional architecture of RNA polymerase I.

Cell - 28 Dec 2007

Kuhn Claus-D, Geiger Sebastian R, Baumli Sonja, Gartmann Marco, Gerber Jochen, Jennebach Stefan, Mielke Thorsten, Tschochner Herbert, Beckmann Roland, Cramer Patrick

Abstract excerpt

Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43. In the resulting hybrid structure of Pol I, A14/43, the clamp, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18160037
DOI: 10.1016/j.cell.2007.10.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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