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Mechanistic understanding of human SLFN11

17 Sept 2022

Abstract excerpt

Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in response to replication stress and inhibits replication of certain viruses such as the human immunodeficiency virus 1 (HIV-1) by modulating the tRNA pool. SLFN11 has been identified as a predictive biomarker in cancer, as its expression...

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PMID: 36115853
DOI: 10.1038/s41467-022-33123-0

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