Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM

29 May 2024

Abstract excerpt

Herpes simplex virus 1 (HSV-1), a double-stranded DNA virus, replicates using seven essential proteins encoded by its genome. Among these, the UL30 DNA polymerase, complexed with the UL42 processivity factor, orchestrates leading and lagging strand replication of the 152 kb viral genome. UL30 polymerase is a prime target for antiviral therapy, and resistance to current drugs can arise in immunocompromised...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Plant Virus Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38806233
DOI: 10.1093/nar/gkae374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EMPMID 38806233Read ↗

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changesSemantic proximity Read ↗

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcriptionSemantic proximity Read ↗

The herpes simplex virus alkaline nuclease is required to maintain replication fork progressionSemantic proximity Read ↗

Cryo-EM structures of human RNA polymerase ISemantic proximity Read ↗

The three-component helicase/primase complex of herpes simplex virus-1Semantic proximity Read ↗

Structure of the measles virus ternary polymerase complexSemantic proximity Read ↗

The Ins and Outs of Herpesviral Capsids: Divergent Structures and Assembly Mechanisms across the Three SubfamiliesSemantic proximity Read ↗

Structure of the herpes simplex virus 1 capsid with associated tegument protein complexesSemantic proximity Read ↗

Atomic structure of the Epstein-Barr virus portalSemantic proximity Read ↗

Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150Semantic proximity Read ↗

Temporal Viral Genome-Protein Interactions Define Distinct Stages of Productive Herpesviral InfectionSemantic proximity Read ↗

Seeing the Herpesvirus Capsid at 8.5 ÅSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.