Article

The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

2022-11-23

Abstract excerpt

Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prolactin receptor (PRLR), the role of lipids in PRLR signalling is unclear. Using an integrative approach combining NMR spectroscopy, cellular signalling experiments, comp...

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Literature Corpus work: 584e0b45-fa32-5bdf-8c2b-7d8aba9e16a9
DOI: 10.1101/2022.11.23.517650

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