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Article

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.

Journal of molecular biology - 11 Aug 2006

Pirruccello Michelle, Sondermann Holger, Pelton Jeffrey G, Pellicena Patricia, Hoelz André, Chernoff Jonathan, Wemmer David E, Kuriyan John

Abstract excerpt

The p21-activated kinases (PAKs) are serine/threonine kinases that are involved in a wide variety of cellular functions including cytoskeletal motility, apoptosis, and cell cycle regulation. PAKs are inactivated by blockage of the active site of the kinase domain by an N-terminal regulatory domain. GTP-bound forms of Cdc42 and Rac bind to the regulatory domain and displace it, thereby allowing phosphorylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16837009
DOI: 10.1016/j.jmb.2006.06.017

Genes

PAK1
PAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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