Article
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).
The Journal of biological chemistry - 23 Nov 2012
Rosenhouse-Dantsker Avia, Noskov Sergei, Han Huazhi, Adney Scott K, Tang Qiong-Yao, Rodríguez-Menchaca Aldo A, Kowalsky Gregory B, Petrou Vasileios I, Osborn Catherine V, Logothetis Diomedes E, Levitan Irena
Abstract excerpt
BACKGROUND: Cholesterol modulates inwardly rectifying potassium (Kir) channels. RESULTS: A two-way molecular cytosolic switch controls channel modulation by cholesterol and PI(4,5)P(2). CONCLUSION: Cholesterol and PI(4,5)P(2) induce a common gating pathway of Kir2.1 despite their opposite impact on channel function. SIGNIFICANCE: These findings provide insights into structure-function relationship of ion channels...
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