Article
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.
Science (New York, N.Y.) - 16 May 2014
Brooks Andrew J, Dai Wei, O'Mara Megan L, Abankwa Daniel, Chhabra Yash, Pelekanos Rebecca A, Gardon Olivier, Tunny Kathryn A, Blucher Kristopher M, Morton Craig J, Parker Michael W, Sierecki Emma, Gambin Yann, Gomez Guillermo A, Alexandrov Kirill, Wilson Ian A, Doxastakis Manolis, Mark Alan E, Waters Michael J
Abstract excerpt
Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of biology and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic. We present a complete mechanistic model for activation of receptor-bound JAK2, based on an archetypal cytokine receptor, the growth hormone receptor. For...
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