Article
The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014
Blind Raymond D, Sablin Elena P, Kuchenbecker Kristopher M, Chiu Hsiu-Ju, Deacon Ashley M, Das Debanu, Fletterick Robert J, Ingraham Holly A
Abstract excerpt
The signaling phosphatidylinositol lipids PI(4,5)P2 (PIP2) and PI(3,4,5)P3 (PIP3) bind nuclear receptor 5A family (NR5As), but their regulatory mechanisms remain unknown. Here, the crystal structures of human NR5A1 (steroidogenic factor-1, SF-1) ligand binding domain (LBD) bound to PIP2 and PIP3 show the lipid hydrophobic tails sequestered in the hormone pocket, as predicted. However, unlike classic nuclear...
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