Article

Phosphorylation of a conserved intrinsically disordered region is necessary for activation of a bacterial Hanks-type Ser/Thr kinase signaling pathway

2025-11-02

Abstract excerpt

Intrinsically disordered regions (IDRs) are found throughout all domains of life, yet their contribution to bacterial signaling has remained unclear. Here we show that phosphorylation of a conserved juxtamembrane IDR is necessary for activation of the bacterial Hanks-type Ser/Thr kinase-phosphatase PrkC/PrpC signaling pathway in Bacillus subtilis . Phosphoablative mutation of a conserved IDR phosphosite has stron...

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Literature Corpus work: 8c8e9826-eb38-50c0-a7f4-b6cbf6ca1761
DOI: 10.1101/2025.11.01.686061

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Phosphorylation of a conserved intrinsically disordered region is necessary for activation of a bacterial Hanks-type Ser/Thr kinase signaling pathwayDOI 10.1101/2025.11.01.686061Read

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