Article

Investigating the interaction of the PKB PH domain with inositol phosphate-based compounds

2013-01-01

Abstract excerpt

Protein kinase B (PKB) plays a key role in the phosphoinositide 3-kinase pathway, one of the most frequently activated proliferation pathways in cancer. A key stage in this pathway is PKB's translocation to the plasma membrane, which is driven by direct interaction of PKB's pleckstrin homology (PH) domain with the inositol phosphate head-groups of phosphoinositide lipids PtdIns(3,4,5)P3 and PtdIns(3,4)P2. In this...

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Literature Corpus work: ed5a3aac-9843-5465-8297-3ca32c3392c4
DOI: 10.25560/39339

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