Article

K-Ras G-domain binding with signaling lipid phosphoinositides: PIP2 association, orientation, function

2018-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Ras genes are potent drivers of human cancers, with mutated K-Ras4B being the most abundant isoform. Targeted inhibition of oncogenic gene products is considered the holy grail of present-day cancer therapy, and recent discoveries of small molecule inhibitors for K-Ras4B greatly benefited from a deeper understanding of the protein structure and dynamics of the GTPase. Since interactions with bio...

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Literature Corpus work: 7651fd82-1cc4-5c7b-92cc-9240a4370b2f
DOI: 10.1101/324210

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