Article

Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying the Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001)

2024-02-06

Abstract excerpt

Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical candidate, MnTnBuOE-2-PyP5+ (BMX-001, MnBuOE), using single-cell analysis in murine carcinoma model. Mice bearing 4T1 tu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 583d652f-1147-5486-af6b-c9e6a37274ca
DOI: 10.20944/preprints202402.0355.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying the Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001)DOI 10.20944/preprints202402.0355.v1Read

Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor modelSemantic proximity Read

Multi-compartment immune and tumor cell reprogramming by IFNα2 overcomes colon cancer immunotherapy resistanceSemantic proximity Read

BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanomaSemantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read

Precision Nanotherapy for p53-Mutant Cancer Using Modular Triple-LNP DeliverySemantic proximity Read

Theranostic Radiopharmaceuticals Targeting Cancer-Associated Fibroblasts.Semantic proximity Read

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrumSemantic proximity Read

Resiquimod-encapsulated MOF525 for Sustained Immunostimulant Release and Synergistic Photodynamic– Immunotherapy in Colorectal CancerSemantic proximity Read

Photodynamic Therapy and Tumor Microenvironment-Targeting Strategies: A Novel Synergy at the Frontier of Cancer TreatmentSemantic proximity Read

High-throughput heterospheroid-based screening identifies drugs that reprogram tumor-associated macrophagesSemantic proximity Read

A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapySemantic proximity Read

ACB1801 enhances tumor immunogenicity by targeting glycolysis/ferroptosis vulnerability and activating STAT1-signaling to overcome anti-PD-1 resistance in MSS colorectal cancerSemantic proximity Read