Precision Nanotherapy for p53-Mutant Cancer Using Modular Triple-LNP Delivery

Abstract excerpt

<title>Abstract</title> <p>This study introduces a novel modular lipid nanoparticle (LNP) platform designed to combat cancers driven by mutant TP53 (p53)—one of the most pervasive genetic alterations in malignancies. The system integrates three mechanistically distinct LNPs: one delivering proteolysis-targeting chimeras (PROTACs) for targeted degradation of mutant p53, another encapsulating the small molecule APR...

Topics

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• Antibodies, Monoclonal
• CD8-Positive T-Lymphocytes
• Cell Line, Tumor
• Mice
• Mutation
• Nanoparticles
• Neoplasms
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

2bdacb9c-9ecc-51dd-a20e-c45a4ed18b96

DOI

10.21203/rs.3.rs-6858679/v1