Article

A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy

2025-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-associated macrophages (TAMs) can switch between immune-activating and cancer-promoting states; yet, the stress pathways that lock them into pro-cancerous states remain obscure. In MC38 colon tumors, repeated anti-CD40 or radiotherapy created necrosis that split TAMs into peripheral Cxcl9+ and peri-necrotic Spp1+ subsets. Spatial transcriptomics, single-cell RNA-seq, and Keap1-deficient mi...

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Literature Corpus work: 1697e0d6-121f-5051-b063-3a3384a88378
DOI: 10.1101/2025.07.02.662726

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