Article

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

2021-12-25

Abstract excerpt

Immune checkpoint therapy (ICT) has the potency to eradicate cancer but the mechanisms that determine effective versus non-effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling we examined whether T cell states in the blood circulation could predict responsiveness to a combined ICT, sequentially targeting OX40 costimulatory and PD-1 inhibitory path...

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Literature Corpus work: c2ad5ab8-f3e2-5081-a451-4c8b41f2f7f4
DOI: 10.1101/2021.12.24.474145

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OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrumDOI 10.1101/2021.12.24.474145Read

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