Back to search

Article

Resiquimod-encapsulated MOF525 for Sustained Immunostimulant Release and Synergistic Photodynamic– Immunotherapy in Colorectal Cancer

2026-01-14

Abstract excerpt

<title>Abstract</title> <p> Metal-organic frameworks (MOFs) represent a novel class of materials with exceptional potential for biomedical applications. In this study, we present MOF525, a porphyrin-based MOF, as a dual-functional platform for photodynamic therapy (PDT) and immunotherapy in the treatment of colorectal cancer. MOF525 encapsulates Resiquimod (R848), a potent Toll-like receptor 7/8 agonist, thereby...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4a897c51-dbe7-5ede-83ca-80bb0ceccff5
DOI
10.21203/rs.3.rs-8452162/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Resiquimod-encapsulated MOF525 for Sustained Immunostimulant Release and Synergistic Photodynamic– Immunotherapy in Colorectal CancerDOI 10.21203/rs.3.rs-8452162/v1
Sequential Ubiquitination and Phosphorylation Epigenetics Reshaping by MG132‐Loaded Fe‐MOF Disarms Treatment Resistance to Repulse Metastatic Colorectal CancerSemantic proximity
Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework NanoparticlesSemantic proximity
Exploring the theranostic potential of carbon dots/Fe3 O4 superparticles for tumor-associated macrophage targeting and repolarization in colorectal cancer therapy via JAK/STAT and ERK/MAPK pathwaysSemantic proximity
Engineered MoS₂ Nanoplatforms for Drug-Enhanced Cancer Phototherapy: From Design Strategies to Translational OpportunitiesSemantic proximity
Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancerSemantic proximity
Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptorsSemantic proximity
Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying the Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001)Semantic proximity
Applications of Boron cluster Supramolecular Frameworks as Metal-free Chemodynamic Therapy AgentsSemantic proximity
Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapySemantic proximity
Nanocatalytic Innate Immunity Activation by Mitochondrial DNA Oxidative Damage for Tumor‐Specific TherapySemantic proximity
Tumor Microenvironment-Responsive CA@ZIF-8/MnO 2 Nanoreactor for Self-Reinforcing Cascade Chemodynamic Therapy and ImmunomodulationSemantic proximity
Nanomedicine Strategies to Overcome Multi-Drug Resistance in Cancer: Innovations in Targeted Delivery, Tumor Microenvironment Modulation and Synergistic TherapiesSemantic proximity
Select a neighboring publication to make it the new centre.