Article

High-throughput heterospheroid-based screening identifies drugs that reprogram tumor-associated macrophages

2025-11-05

Abstract excerpt

The tumor microenvironment (TME) provides a niche for immune evasion and immunotherapy resistance, in part, by recruiting pro-tumor M2-like macrophages. In the present study, using heterospheroids consisting of cancer cells and macrophages, we identified TAM activators, which are compounds that reprogram M2-like tumor-associated macrophages (TAMs) toward the antitumor M1-like phenotype. THP-1- or human peripheral...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f02f253-06e2-5722-9c9e-e4ae34157aec
DOI: 10.1101/2025.11.04.686451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput heterospheroid-based screening identifies drugs that reprogram tumor-associated macrophagesDOI 10.1101/2025.11.04.686451Read

Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma.Semantic proximity Read

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.Semantic proximity Read

Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotypeSemantic proximity Read

Tumor-associated macrophages: functional diversity, clinical significance, and open questions.Semantic proximity Read

Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacologySemantic proximity Read

Functional Genetic Screens Reveal Key Pathways Instructing the Molecular Phenotypes of Tumor-Associated MacrophagesSemantic proximity Read

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasisSemantic proximity Read

Targeting human M2 macrophages with antibodies in optimized 3D tumor spheroidsSemantic proximity Read

Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor- associated macrophages in glioblastomaSemantic proximity Read

Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastomaSemantic proximity Read

Bidirectional phenotypic transition in macrophages influences triple-negative breast cancer cell immune evasive patterns and response to chemotherapies in a co-culture spheroid model.Semantic proximity Read

PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophagesSemantic proximity Read