Article

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast Cancers

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Patients diagnosed with metastatic triple negative breast cancer (mTNBC) have limited treatment options, are more prone to develop resistance and are associated with high mortality. A cold tumor immune microenvironment (TIME) characterized by low T cells and high tumor associated macrophages (TAMs) in mTNBC is associated with the failure of standard-of-care chemotherapy and immune checkpoint blo...

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Literature Corpus work: ed5b80cb-2e77-54e7-98a8-5a8fb7c36757
DOI: 10.1101/2025.04.30.651522

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