Article

A conserved mechanism for regulation of mtDNA copy number in eukaryotes

2026-05-31

Abstract excerpt

Mitochondrial mass and mitochondrial DNA (mtDNA) copy number are coupled to metabolic demand at the cellular, tissue and organismal level, however, the molecular basis for homeostatic regulation of mtDNA is not understood. Here we show that mitochondria and mtDNA copy number are regulated by compartmentalisation of iron-sulfur (Fe-S) clusters, glutathione and cysteine, a mechanism we exemplify in model systems ran...

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Literature Corpus work: 582b972b-92c8-5ded-a44b-5478dc638de6
DOI: 10.64898/2026.05.29.727956

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