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Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma

1 Jun 2023

Abstract excerpt

Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. Here, we utilize RNA sequencing and metabolomics to identify candidate molecular effectors activated by these genetic drivers. We find glutathione biosynthesis, amino acid metabolism, mitochondrial unfolded protein response, and lipid peroxide scavenging...

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PMID: 37262067
DOI: 10.1158/2159-8290.cd-22-0976

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