Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity

Abstract excerpt

Of the ∼1100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive force (PMF) to execute signaling roles. To systematically identify genes that increase exclusively at the protein level upon PMF collapse, we performed a joint proteomic and RNA-seq screen. The screen revealed 10 candidates (six mitochondrial), including the vitamin B12...

Topics

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• Adipose Tissue and Metabolism
• ATP Synthase and ATPases Research
• Dynamins
• Endoplasmic Reticulum Stress and Disease
• Mitochondrial Dynamics
• Mitochondrial Function and Pathology
• Mutation
• Protein Isoforms

Identifiers and source

Literature Corpus work

50c76bd2-c967-5718-a85b-7613c6fab814

DOI

10.64898/2025.12.31.697091