Article

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation

2025-10-27

Abstract excerpt

Human mitochondrial DNA (mtDNA) encodes 13 essential components of the electron transport chain (ETC) 1 . A typical cell contains ∼1000s of copies of mtDNA, but how this copy number is stably maintained is unclear. Here, we track mtDNA copy number (mtCN) recovery in K562 cells following transient, chemically induced depletion to uncover principles of mtCN stability. Below a critical mtCN, ETC activity fails to su...

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Literature Corpus work: 63812d45-7450-5414-81f5-a8b9d83970d5
DOI: 10.1101/2025.10.27.684790

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