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Mitochondrial iron-sulfur protein biogenesis and human disease.

Biochimie - 1 May 2014

Stehling Oliver, Wilbrecht Claudia, Lill Roland

Abstract excerpt

Work during the past 14 years has shown that mitochondria are the primary site for the biosynthesis of iron-sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria essential for viability of virtually all eukaryotes, because they participate in the synthesis of the Fe/S clusters of key nuclear and cytosolic proteins such as DNA polymerases, DNA helicases, and ABCE1 (Rli1), an ATPase involved...

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Identifiers

PMID: 24462711
DOI: 10.1016/j.biochi.2014.01.010

Genes

ABCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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