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Article

Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.

Molecular biology of the cell - 1 Jul 2026

Lane Alicia R, Gonzalez Nadia, Gokhale Avanti, Zlatic Stephanie A, Allen Brooke M, Scher Noah E, Roberts Anne M, Duong Duc M, Roberts Blaine R, Vrailas-Mortimer Alysia D, Werner Erica, Faundez Victor

Abstract excerpt

Impairments to the complex machinery regulating copper homeostasis lead to neurodevelopmental diseases, demonstrating the importance of copper for neuronal health and maintenance. The exact mechanisms by which the brain responds to copper deficiency following disruptions to the copper transporters ATP7A and CTR1 in conditions such as Menkes disease remain unclear, though failure to supply complex IV of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42126960
DOI: 10.1091/mbc.E26-01-0021
PMCID: PMC13329850

Genes

COX17
ATP7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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