Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.

Nature structural & molecular biology - 1 Apr 2026

Burr Stephen P, Auckland Kathryn, Glynos Angelos, Dhawanjewar Abhilesh, Ryall Cameron, Wei Wei, Hynes-Allen Antony, Prater Malwina, Sczaniecka-Clift Matylda, Prudent Julien, Chinnery Patrick F, van den Ameele Jelle

Abstract excerpt

Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is under strict control by the cell nucleus. mtDNA occurs in many copies per cell and mutations often only affect a proportion of them, giving rise to heteroplasmy. mtDNA copy number and heteroplasmy level together shape the tissue-specific impact of mtDNA mutations, eventually giving rise to both rare mitochondrial and common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

Share to GTP Phosphohydrolases

Share to Heteroplasmy

Share to High Mobility Group Proteins

Share to Single-Cell Analysis

Share to Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41922875
DOI: 10.1038/s41594-026-01779-7
PMCID: PMC13095666

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.PMID 41922875Read ↗

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmySemantic proximity Read ↗

MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulationSemantic proximity Read ↗

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read ↗

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice.Semantic proximity Read ↗

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicismSemantic proximity Read ↗

Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.Semantic proximity Read ↗

Exploring Heteroplasmic Variants in mtDNA: Insights from Single-Cell TranscriptomicsSemantic proximity Read ↗

MitoDelta: identifying mitochondrial DNA deletions at cell-type resolution from single-cell RNA sequencing dataSemantic proximity Read ↗

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs <i>in vivo</i>Semantic proximity Read ↗

Exploring Heteroplasmic Variants in mtDNA: Insights from Single-Cell Transcriptomics.Semantic proximity Read ↗

Mitochondrial DNA copy number reduction via <i>in vitro TFAM</i> knockout remodels the nuclear epigenome and transcriptomeSemantic proximity Read ↗

High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.