Article

Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis

2026-01-14

Abstract excerpt

Impairments to the complex machinery regulating copper homeostasis lead to neurodevelopmental diseases, demonstrating the importance of copper for neuronal health and maintenance. The exact mechanisms by which the brain responds to copper deficiency following disruptions to the copper transporters ATP7A and CTR1 in conditions such as Menkes disease remain unclear, though failure to supply complex IV of the respira...

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Literature Corpus work: 59c6ad79-aa82-5b66-9496-4794485c9e06
DOI: 10.64898/2026.01.13.699066

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