Article

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy

2025-07-11

Abstract excerpt

<h4>Summary</h4> Mitochondria contain their own genome, the mitochondrial DNA (mtDNA), which is under strict control of the cell nucleus. mtDNA occurs in many copies in each cell, and mutations often only affect a proportion of them, giving rise to heteroplasmy. mtDNA copy number and heteroplasmy level together shape the cell- and tissue-specific impact of mtDNA mutations, ultimately giving rise to rare mitochond...

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Literature Corpus work: cb36574d-a7c7-5c0b-bf15-9905b69d01d7
DOI: 10.1101/2025.07.08.663208

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