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Article

Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism.

Biomedical journal - 1 Aug 2025

Hsiung Kuei-Ching, Tang Hsiang-Yu, Cheng Mei-Ling, Hung Li-Man, Chin-Ming Tan Bertrand, Lo Szecheng J

Abstract excerpt

BACKGROUND: CISD-1 is a mitochondrial iron-sulfate [2Fe-2S] protein known to be associated with various human diseases, including cancer and diabetes. Previously, we demonstrated that CISD-1 deficiency in worms lowers glucose and ATP levels. In this study, we further explored how worms compensate for lower ATP levels by analyzing changes in cytoplasmic and mitochondrial iron content, AMPK activities, and total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39521176
DOI: 10.1016/j.bj.2024.100806
PMCID: PMC12319338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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