Article

Open/close ratio reveals cell differentiation state as the primary determinant of chromatin balance in immune memory

2026-04-25

Abstract excerpt

<title>Abstract</title> <p>Trained immunity involves epigenetic reprogramming of innate immune cells, yet the genome-wide balance between chromatin opening and closing during this process has not been systematically quantified. Here, we introduce the open/close ratio, a single metric that captures the global chromatin accessibility balance by dividing the number of regions gaining accessibility by those losing it...

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Literature Corpus work: 5815435c-5692-5504-8935-21f8630bb3e9
DOI: 10.21203/rs.3.rs-9364995/v1

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