Article

Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease

2023-12-26

Abstract excerpt

Enhancers and transcription factors (TFs) are crucial in regulating cellular processes, including disease-associated cell states. Current multiomic technologies to study these elements in gene regulatory mechanisms lack multiplexing capability and scalability. Here, we present SUM-seq, a cost-effective, scalable S ingle-cell U ltra-high-throughput M ultiomic sequencing method for co-assaying chromatin accessibi...

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Literature Corpus work: 8cf203eb-bda7-5a8c-bd2c-0f25d7340e46
DOI: 10.1101/2023.12.26.573253

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